As a guy with many vehicles that I don't really have a particular daily and if I am in your shoes there are a couple things I would avoid.
I would not want any engine that has a turbo. Period. If that ever fails your repair bill will have surpassed any lifetime savings in fuel. Just too complicated and too many things to fail.
The newer the vehicle the more electrical issues you will run into. There seems to be a lot of vehicles that are 5 years old for sale. Is that because people are worrying about currentor future electrical issues? Today's cars run the risk of being totaled by the insurance company for electrical issues.
Direct injection is just asking for carbon issues, especially if putzing around town. Port injection does not have these issues. Most makers have shifted to direct knowing the carbon issue but are more intent on reported mpg rather than customer satisfaction. Toyota and Ford have direct and port hybrid systems. Ford hybrid is only available on their 4.6 and 5.0 V8.
Ford cam phaser issue. This is common on the 5.0 and non existent on the 4.6. I have many work trucks with the 4.6 and several are in the 400k area.
Transmissions. 10 speed is such a POS every maker is facing lawsuits as they all used them.
If I was in need of only 1 vehicle I would buy a 2015-2017 F150 super cab. Aluminum body, 5.0 and the 6 speed transmission. Trim package based upon availability.