Tubing size absolutely makes a difference. Unfortunately the variables are so complex it takes a very involved CFD simulation to accurately predict what will happen when changing the length of the diameter of an intake.
My Windstar intake has one heck of a resonance at WOT and 2,200 to 2,500 RPM and also 4,400 to 5,000 or so RPM to a lesser degree. Fuel trims seem to go quite positive in these bands, so I probably inadvertently created some volumetric efficiency peaks there.
For a while I debated going large diameter on the entire intake, but have decided against it as those peaks I have are already at super convenient RPM bands for freeway use. While I couldn't say for sure without testing, I suspect going large might eliminate those two bands.